Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3039120 | 0.85 | POLB (0.58) | IMPDH2SMN1; SMN2HDAC1HDAC6CYP3A4 | |
| SCHEMBL3836272 | 0.83 | RAB9A (0.57) | RAB9ANPC1IMPDH2ALDH1A1LMNA | |
| SCHEMBL94229 | 0.82 | IMPDH2 (0.52) | RAB9AIMPDH2SMN1; SMN2LMNAHDAC1 | |
| SCHEMBL3838597 | 0.82 | IMPDH2 (0.52) | RAB9ANPC1HPGDIMPDH2ALDH1A1 | |
| SCHEMBL3836954 | 0.81 | IMPDH2 (0.51) | RAB9ANPC1IMPDH2MAPTSMN1; SMN2 | |
| SCHEMBL3835902 | 0.81 | PPARG (0.52) | RAB9ANPC1KCNK3IMPDH2ALDH1A1 | |
| SCHEMBL3835811 | 0.81 | POLB (0.56) | RAB9ANPC1IMPDH2ALDH1A1MAPT | |
| SCHEMBL25754043 | 0.80 | HDAC1 (0.58) | RAB9ANPC1HPGDKCNK3ALDH1A1 | |
| SCHEMBL3834428 | 0.78 | ROCK2 (0.49) | RAB9ANPC1IMPDH2ALDH1A1LMNA | |
| SCHEMBL3860731 | 0.78 | EPHX2 (0.50) | RAB9AIMPDH2ALDH1A1LMNAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |