Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 3/20 | 0.48 |
| ▸ | CLK1 | P49759 | 2/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 3/20 | 0.43 |
| ▸ | CDK8 | P49336 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628791 | 0.86 | MKNK1 (0.45) | EP300CLK1ACACBHDAC8CCNC | |
| SCHEMBL14713190 | 0.86 | MKNK1 (0.45) | EP300CLK1ACACBHDAC8CCNC | |
| Hydrochloric Acid SCHEMBL540914 | 0.85 | MKNK1 (0.44) | EP300CLK1ACACBHDAC8CCNC | |
| SCHEMBL12001659 | 0.79 | ACACB (0.68) | EP300ACACBCCNCCDK8 | |
| SCHEMBL24043580 | 0.78 | ITGA4 (0.54) | GSK3BDYRK1A | |
| SCHEMBL25242176 | 0.78 | MAPK8 (0.51) | CLK1CCNCCDK8GSK3BDYRK1A | |
| SCHEMBL6576829 | 0.77 | ALDH1A1 (0.55) | ACACBMME | |
| SCHEMBL25243707 | 0.76 | MKNK1 (0.43) | EP300CLK1CCNCCDK8MKNK1 | |
| SCHEMBL13984679 | 0.76 | MKNK1 (0.57) | CLK1CCNCCDK8MKNK1MKNK2 | |
| SCHEMBL25356081 | 0.76 | SLC7A5 (0.50) | EP300HDAC8CCNCCDK8MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11685725-B2 | YAP1 inhibitors that target the interaction of YAP1 with OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2023-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11685725-B2 | YAP1 inhibitors that target the interaction of YAP1 with OCT4 | YAP1, YES1, MYC | EP300 1115/4885CLK1 2973/4885ACACB 4559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.