Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23833733 | 0.89 | POLB (0.54) | POLBL3MBTL1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL25754734 | 0.88 | POLB (0.55) | POLBL3MBTL1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL25754724 | 0.88 | L3MBTL1 (0.61) | POLBL3MBTL1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL30199628 | 0.86 | POLB (0.56) | POLBL3MBTL1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL23833774 | 0.86 | POLB (0.56) | POLBL3MBTL1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL25754681 | 0.84 | MEN1 (0.73) | POLBL3MBTL1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL25754684 | 0.83 | HPGD (0.62) | POLBL3MBTL1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL25754747 | 0.82 | ALPL (0.55) | POLBL3MBTL1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL25754679 | 0.82 | SMN1; SMN2 (0.64) | POLBHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL25754699 | 0.82 | SMN1; SMN2 (0.54) | L3MBTL1SMN1; SMN2ALDH1A1LMNATBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | US | disclosed |
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | TRAP1, PINK1, TP53BP1 | POLB 1494/4885L3MBTL1 2375/4885HPGD 2112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.