SCHEMBL25759300

SCHEMBL25759300

O=S(=O)(NCCN1CCC(Cc2ccccc2)CC1)c1ccc(Oc2ccccc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PRMT6 Q96LA8 3/20 0.54
CARM1 Q86X55 2/20 0.54
TMEM97 Q5BJF2 2/20 0.53
SIGMAR1 Q99720 2/20 0.53
KMT2A Q03164 2/20 0.52
MEN1 O00255 1/20 0.52
HTT P42858 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
SLC6A2 P23975 1/20 0.49
SLC6A3 Q01959 1/20 0.49
CCR3 P51677 1/20 0.49
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA9 Q16790 1/20 0.48
KDM1A O60341 1/20 0.48
PRMT3 O60678 1/20 0.48
PRMT1 Q99873 1/20 0.48
PRMT8 Q9NR22 1/20 0.48
KDM4E B2RXH2 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25758331 0.94 MEN1 (0.58) TMEM97SIGMAR1KMT2AMEN1HTT
SCHEMBL25758458 0.87 SLC6A2 (0.61) PRMT6CARM1KMT2AMEN1HTT
SCHEMBL23648940 0.86 TMEM97 (0.58) PRMT6CARM1TMEM97SIGMAR1KMT2A
SCHEMBL24069354 0.86 PRMT6 (0.56) PRMT6CARM1KMT2AMEN1HTT
SCHEMBL25759276 0.86 PRMT6 (0.56) PRMT6CARM1KMT2AMEN1HTT
SCHEMBL25248038 0.84 HTR7 (0.63) PRMT6CARM1KMT2ASMN1; SMN2SLC6A2
SCHEMBL25758335 0.84 HTR7 (0.62) KMT2AMEN1HTTSMN1; SMN2SLC6A2
SCHEMBL30376178 0.82 HTR7 (0.69) PRMT6CARM1TMEM97SIGMAR1KMT2A
SCHEMBL24070204 0.82 HTR7 (0.56) TMEM97SIGMAR1KMT2AMEN1HTT
SCHEMBL26213100 0.82 KMT2A (0.48) PRMT6CARM1SIGMAR1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116157124-A Sulfonamide derivative and pharmaceutical composition for preventing or treating mental diseases containing the same as active ingredient 大邱庆北尖端医疗产业振兴财团 2023-05-23 CN claimed
US-20230212121-A1 SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING MENTAL ILLNESS TRINEURO (KR) 2023-07-06 US disclosed
CN-116157124-A Sulfonamide derivative and pharmaceutical composition for preventing or treating mental diseases containing the same as active ingredient 大邱庆北尖端医疗产业振兴财团 2023-05-23 CN disclosed
EP-4159718-A1 SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING MENTAL ILLNESS Daegu-Gyeongbuk Medical Innovation Foundation (KR) 2023-04-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230212121-A1 SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING MENTAL ILLNESS SLC6A2, SLC6A3, SLC6A4 PRMT6 2897/4885CARM1 4741/4885TMEM97 1179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.