Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Dyclonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 9/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.90 |
| ▸ | LMNA | P02545 | 7/20 | 0.90 |
| ▸ | HRH2 | P25021 | 4/20 | 0.90 |
| ▸ | HRH1 | P35367 | 4/20 | 0.90 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.90 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.90 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.90 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.90 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.90 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.90 |
| ▸ | DRD4 | P21917 | 1/20 | 0.90 |
| ▸ | ACHE | P22303 | 1/20 | 0.90 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.90 |
| ▸ | HTR2A | P28223 | 1/20 | 0.90 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.90 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.90 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29766083 | 0.95 | THRB (1.00) | THRBALDH1A1LMNAHRH2HRH1 | |
| Dyclonine SCHEMBL25773 | 0.95 | THRB (1.00) | THRBALDH1A1LMNAHRH2HRH1 | |
| Dyclonine SCHEMBL317219 | 0.94 | THRB (1.00) | THRBALDH1A1LMNAHRH2HRH1 | |
| Dyclonine SCHEMBL1649948 | 0.93 | THRB (0.95) | THRBALDH1A1LMNAHRH2HRH1 | |
| SCHEMBL11231907 | 0.91 | THRB (1.00) | THRBALDH1A1LMNAHRH2HRH1 | |
| SCHEMBL9320014 | 0.91 | THRB (1.00) | THRBALDH1A1LMNAHRH2HRH1 | |
| SCHEMBL9319585 | 0.91 | THRB (1.00) | THRBALDH1A1LMNAHRH2HRH1 | |
| SCHEMBL9320006 | 0.91 | THRB (1.00) | THRBALDH1A1LMNAHRH2HRH1 | |
| Hydrochloric Acid SCHEMBL11234596 | 0.90 | THRB (0.98) | THRBALDH1A1LMNAHRH2HRH1 | |
| SCHEMBL29378842 | 0.90 | ALDH1A1 (0.97) | THRBALDH1A1LMNAHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0872248-A2 | Pharmaceutical vehicles for reducing transdermal flux | Access Pharmaceuticals, Inc. (US) | 1998-10-21 | — | — | EP | claimed |