Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Dyclonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 9/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | HRH2 | P25021 | 4/20 | 0.97 |
| ▸ | HRH1 | P35367 | 4/20 | 0.97 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.97 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.97 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.97 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.97 |
| ▸ | DRD4 | P21917 | 1/20 | 0.97 |
| ▸ | ACHE | P22303 | 1/20 | 0.97 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.97 |
| ▸ | HTR2A | P28223 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dyclonine SCHEMBL25773 | 0.99 | THRB (1.00) | THRBALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL29766083 | 0.99 | THRB (1.00) | THRBALDH1A1LMNAMAPTCYP3A4 | |
| Hydrochloric Acid SCHEMBL11234596 | 0.96 | THRB (0.98) | THRBALDH1A1LMNAMAPTCYP3A4 | |
| Dyclonine SCHEMBL1649948 | 0.96 | THRB (0.95) | THRBALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL11231907 | 0.95 | THRB (1.00) | THRBALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL9320014 | 0.95 | THRB (1.00) | THRBALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL9319585 | 0.95 | THRB (1.00) | THRBALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL9320006 | 0.95 | THRB (1.00) | THRBALDH1A1LMNAMAPTCYP3A4 | |
| Propipocaine SCHEMBL4457156 | 0.95 | ALDH1A1 (1.00) | THRBALDH1A1LMNAMAPTCYP3A4 | |
| Dyclonine SCHEMBL8662373 | 0.94 | THRB (0.90) | THRBALDH1A1LMNAMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2846 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4231960-B1 | DENTAL KIT COMPRISING A DENTAL ALIGNER OR A MOUTH TRAY AND DISSOLVABLE FILMS | BSOLVE LTD (GB) | 2026-04-15 | — | — | EP | claimed |
| US-20250195523-A1 | ORGANIC MOLECULES FOR TREATING MYELIN PATHOLOGIES | ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE) (FR) | 2025-06-19 | — | — | US | claimed |
| US-20250143905-A1 | TOPICAL TREATMENT FOR ANORECTAL DISORDERS WITH AND WITHOUT SEAT CUSHION | CUTLER ROBERT S (US) | 2025-05-08 | — | — | US | claimed |
| WO-2025034143-A1 | PHARMACEUTICAL COMPOSITION OF GRAMICIDIN S FOR TREATING INFECTIOUS INFLAMMATORY DISEASES OF THE ORAL CAVITY AND THROAT | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ВАЛЕНТА-ИНТЕЛЛЕКТ" | 2025-02-13 | — | — | WO | claimed |
| EP-4496574-A1 | ORGANIC MOLECULES FOR TREATING MYELIN PATHOLOGIES | ICM (Institut du Cerveau et de la Moelle Épinière) (FR) | 2025-01-29 | — | — | EP | claimed |
| CN-119350149-A | 1- (4-Butoxyphenyl) -3-hydroxypropyl-1-one and preparation method and application thereof | 北京茗泽中和药物研究有限公司 | 2025-01-24 | — | — | CN | claimed |
| CN-119350150-A | 4-Butoxyphenyl propenone and preparation method and application thereof | 北京茗泽中和药物研究有限公司 | 2025-01-24 | — | — | CN | claimed |
| CN-119074731-A | Use of dyclonine hydrochloride in preventing hypothalamic-pituitary-ovarian axis injury in female mice | 湖南师范大学 | 2024-12-06 | — | — | CN | claimed |
| CN-118806831-A | Composition for cooling and stopping bleeding and adhesive bandage | 夏清平 | 2024-10-22 | — | — | CN | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| EP-0321231-A1 | Pharmaceutical compositions | Richardson-Vicks, Inc. (US) | 1989-06-21 | — | — | EP | claimed |
| EP-0316345-A1 | LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE | LIPOSOME TECHNOLOGY, INC. (US) | 1989-05-24 | — | — | EP | claimed |
| EP-0316345-A4 | LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE. | LIPOSOME TECHNOLOGY INC (US) | 1989-05-16 | — | — | EP | claimed |
| US-4808410-A | ORAL HEALTH CARE LIQUIDS OR LOZENGES AS MICROBIOCIDES; SYNERGISTIC | RICHARDSON-VICKS INC. (US) | 1989-02-28 | — | — | US | claimed |
| WO-1989000047-A1 | HEMORRHOIDAL, OTHER COMPOSITIONS AND METHODS OF TREATMENT | PACKMAN ELIAS W (US) | 1989-01-12 | — | — | WO | claimed |
| WO-1988000824-A1 | LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE | LIPOSOME TECHNOLOGY, INC. (US) | 1988-02-11 | — | — | WO | claimed |
| EP-0126684-A2 | Drug delivery system utilizing thermosetting gels | MERCK & CO. INC. (US) | 1984-11-28 | — | — | EP | claimed |
| US-4474751-A | SUSTAINED RELEASE USING AN ALKYLENEDIAMINE-MODIFIED ETHYLENE OXIDE-PROPYLENE OXIDE COPOLYMER | MERCK & CO., INC. (US) | 1984-10-02 | — | — | US | claimed |
| US-4333941-A | Inhibition of enveloped viruses with phenyl ketones | THE DOW CHEMICAL COMPANY (US) | 1982-06-08 | — | — | US | claimed |
| US-4312865-A | Medication having penetration through cutaneous surfaces into articular and muscular areas | SZUCS MURRILL M | 1982-01-26 | — | — | US | claimed |