SCHEMBL257807

SCHEMBL257807

OB(O)c1ccc(-c2cccc(F)c2)cc1F

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 1/20 0.55
TAAR1 Q96RJ0 3/20 0.50
CYP11B2 P19099 2/20 0.44
TNKS2 Q9H2K2 1/20 0.44
PTPN1 P18031 1/20 0.42
HSD17B1 P14061 2/20 0.42
HSD17B2 P37059 2/20 0.42
CYP17A1 P05093 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP11B1 P15538 1/20 0.41
DCLRE1B Q9H816 1/20 0.41
PDK2 Q15119 1/20 0.40
ACHE P22303 1/20 0.39
PGR P06401 1/20 0.39
FFAR1 O14842 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12261275 0.91 ESR2 (0.50) ESR2TAAR1CYP11B2TNKS2PTPN1
SCHEMBL12384874 0.88 ESR2 (0.36) ESR2HSD17B1HSD17B2
SCHEMBL12261117 0.87 MGLL (0.50) ESR2TAAR1CYP11B2HSD17B1HSD17B2
SCHEMBL177425 0.86 MGLL (0.48) ESR2TAAR1CYP11B2HSD17B1HSD17B2
SCHEMBL29955002 0.86 MGLL (0.48) ESR2TAAR1CYP11B2HSD17B1HSD17B2
SCHEMBL12384885 0.86 ESR2 (0.49) ESR2TAAR1CYP11B2TNKS2PTPN1
SCHEMBL14753490 0.85 ACHE (0.45) ESR2HSD17B1HSD17B2PDK2ACHE
SCHEMBL177530 0.84 ESR2 (0.39) ESR2TAAR1CYP11B2TNKS2HSD17B1
SCHEMBL257792 0.83 ESR2 (0.53) ESR2TAAR1CYP11B2TNKS2PTPN1
SCHEMBL257746 0.82 ERN1 (0.42) ESR2TNKS2ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150344503-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE, METHODS OF TREATMENT AND METHODS OF PREPARING SAME INFINITY PHARMACEUTICALS INC (US) 2015-12-03 US claimed
US-20250120311-A1 COMPOUND FOR ORGANIC OPTOELECTRONIC DEVICE, COMPOSITION FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE, AND DISPLAY DEVICE SAMSUNG SDI CO., LTD. (KR) 2025-04-10 US disclosed
EP-4458822-A1 COMPOUND FOR ORGANIC OPTOELECTRONIC DEVICE, COMPOSITION FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE, AND DISPLAY DEVICE Samsung SDI Co., Ltd. (KR) 2024-11-06 EP disclosed
WO-2023128513-A1 COMPOUND FOR ORGANIC OPTOELECTRONIC DEVICE, COMPOSITION FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE, AND DISPLAY DEVICE 삼성에스디아이 주식회사 2023-07-06 WO disclosed
US-20180244700-A1 METHODS OF TREATING A FATTY ACID AMIDE HYDROLASE-MEDIATED CONDITION INFINITY PHARMACEUTICALS, INC. 2018-08-30 US disclosed
US-9951089-B2 Methods of treating a fatty acid amide hydrolase-mediated condition INFINITY PHARMACEUTICALS, INC. (US) 2018-04-24 US disclosed
US-9951089-B2 Methods of treating a fatty acid amide hydrolase-mediated condition INFINITY PHARMACEUTICALS, INC. (US) 2018-04-24 US disclosed
US-9951089-B2 Methods of treating a fatty acid amide hydrolase-mediated condition INFINITY PHARMACEUTICALS, INC. (US) 2018-04-24 US disclosed
US-20150344503-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE, METHODS OF TREATMENT AND METHODS OF PREPARING SAME INFINITY PHARMACEUTICALS INC (US) 2015-12-03 US disclosed
US-20150344503-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE, METHODS OF TREATMENT AND METHODS OF PREPARING SAME INFINITY PHARMACEUTICALS INC (US) 2015-12-03 US disclosed
US-20110201574-A1 FATTY ACID AMIDE HYDROLASE INHIBITORS INFINITY PHARMACEUTICALS, INC. 2011-08-18 US disclosed
US-20110201574-A1 FATTY ACID AMIDE HYDROLASE INHIBITORS INFINITY PHARMACEUTICALS, INC. 2011-08-18 US disclosed
US-20110201574-A1 FATTY ACID AMIDE HYDROLASE INHIBITORS INFINITY PHARMACEUTICALS, INC. 2011-08-18 US disclosed
WO-2011097233-A1 FATTY ACID AMIDE HYDROLASE INHIBITORS INFINITY PHARMACEUTICALS, INC. (US) 2011-08-11 WO disclosed
WO-2011097233-A1 FATTY ACID AMIDE HYDROLASE INHIBITORS INFINITY PHARMACEUTICALS, INC. (US) 2011-08-11 WO disclosed
US-7947663-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2011-05-24 US disclosed
US-7947663-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2011-05-24 US disclosed
US-20090099131-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY DISCOVERY, INC. (US) 2009-04-16 US disclosed
US-20090099131-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY DISCOVERY, INC. (US) 2009-04-16 US disclosed
WO-2008063300-A2 BORONIC ACIDS AND ESTERS AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2008-05-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110201574-A1 FATTY ACID AMIDE HYDROLASE INHIBITORS FAAH, FAAH2, FASN ESR2 3039/4885TAAR1 2103/4885CYP11B2 3327/4885
US-20180244700-A1 METHODS OF TREATING A FATTY ACID AMIDE HYDROLASE-MEDIATED CONDITION FAAH, FAAH2, FASN ESR2 2277/4885TAAR1 2133/4885CYP11B2 2852/4885
US-20090099131-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 ESR2 4177/4885TAAR1 616/4885CYP11B2 835/4885
US-20150344503-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE, METHODS OF TREATMENT AND METHODS OF PREPARING SAME FAAH, FAAH2, ASAH1 ESR2 4255/4885TAAR1 745/4885CYP11B2 772/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.