SCHEMBL2578992

SCHEMBL2578992

CN[C@H](C)c1ncc(Cl)cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
CYP2C9 P11712 1/20 0.39
TSHR P16473 1/20 0.39
APEX1 P27695 1/20 0.39
KMT2A Q03164 2/20 0.38
IDH1 O75874 1/20 0.36
S1PR1 P21453 1/20 0.35
S1PR3 Q99500 1/20 0.35
MEN1 O00255 1/20 0.35
HTT P42858 1/20 0.35
HSD17B10 Q99714 1/20 0.35
PLAU P00749 1/20 0.34
MAPK1 P28482 1/20 0.34
CRHR1 P34998 2/20 0.34
HTR2A P28223 2/20 0.33
SLC6A4 P31645 2/20 0.33
KCNH2 Q12809 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2578995 1.00 LMNA (0.39) LMNASMN1; SMN2CYP2C9TSHRAPEX1
SCHEMBL2609312 0.79 LMNA (0.44) LMNASMN1; SMN2CYP2C9TSHRAPEX1
SCHEMBL18244479 0.78 LMNA (0.42) LMNASMN1; SMN2CYP2C9TSHRAPEX1
SCHEMBL31518746 0.76 LMNA (0.41) LMNASMN1; SMN2CYP2C9TSHRAPEX1
SCHEMBL16043880 0.76 LMNA (0.44) LMNASMN1; SMN2CYP2C9TSHRAPEX1
SCHEMBL16044116 0.76 LMNA (0.44) LMNASMN1; SMN2CYP2C9TSHRAPEX1
SCHEMBL6030679 0.76 LMNA (0.44) LMNASMN1; SMN2CYP2C9TSHRAPEX1
SCHEMBL22320215 0.73 SMN1; SMN2 (0.39) LMNASMN1; SMN2CYP2C9TSHRAPEX1
SCHEMBL22530398 0.73 LMNA (0.39) LMNASMN1; SMN2CYP2C9TSHRAPEX1
SCHEMBL22193246 0.73 CRHR1 (0.40) LMNASMN1; SMN2CYP2C9TSHRAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8586611-B2 Fungicidal carboxamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2013-11-19 US disclosed
EP-1948649-B1 FUNGICIDAL CARBOXAMIDES DU PONT (US) 2013-06-26 EP disclosed
US-20110269712-A1 Fungicidal Carboxamides BISAHA JOHN JOSEPH 2011-11-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110269712-A1 Fungicidal Carboxamides NAT1, PFAS, CHRM1 LMNA 2084/4885SMN1; SMN2 3646/4885CYP2C9 154/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.