Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2580833 | 0.87 | ALDH1A1 (0.53) | GAASMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL4265115 | 0.81 | NPC1 (0.47) | TP53SMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL5530069 | 0.75 | HDAC1 (0.42) | TP53SMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL15300384 | 0.74 | MAPT (0.43) | TP53SMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL2587331 | 0.73 | GAA (0.49) | GAATP53SMN1; SMN2KMT2ALMNA | |
| SCHEMBL13545878 | 0.72 | GAA (1.00) | GAATP53SMN1; SMN2KMT2ALMNA | |
| SCHEMBL4263116 | 0.71 | LMNA (0.56) | GAASMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL2588184 | 0.69 | MAPT (0.63) | GAASMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL4263699 | 0.68 | MAPT (0.60) | GAASMN1; SMN2KMT2ALMNANAMPT | |
| SCHEMBL2585124 | 0.66 | LMNA (0.60) | GAASMN1; SMN2KMT2ALMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |