SCHEMBL5530069

SCHEMBL5530069

Cc1nn(-c2ccccc2)nc1C(=O)N1CCc2onc(OC(=O)NCc3ccc(F)cc3)c2C1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 3/20 0.42
KMT2A Q03164 4/20 0.41
LMNA P02545 4/20 0.41
MEN1 O00255 2/20 0.41
TSHR P16473 2/20 0.41
MAPK1 P28482 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
ALDH1A1 P00352 3/20 0.40
SIGMAR1 Q99720 1/20 0.37
NPC1 O15118 3/20 0.37
MAPT P10636 2/20 0.37
RAB9A P51151 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
HPGD P15428 1/20 0.36
TP53 P04637 2/20 0.36
ADORA2A P29274 1/20 0.36
HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2580833 0.88 ALDH1A1 (0.53) HDAC1KMT2ALMNAMEN1TSHR
SCHEMBL15300384 0.84 MAPT (0.43) KMT2ALMNATSHRNPSR1ALDH1A1
SCHEMBL5536542 0.79 L3MBTL1 (0.47) KMT2ALMNAMEN1TSHRMAPK1
SCHEMBL4265115 0.76 NPC1 (0.47) KMT2ALMNATSHRNPSR1ALDH1A1
SCHEMBL5532207 0.74 GRM5 (0.39) HDAC1KMT2ALMNAMEN1TSHR
SCHEMBL2580660 0.67 ALDH1A1 (0.60) KMT2ALMNAMEN1TSHRMAPK1
SCHEMBL5525684 0.65 GRM5 (0.41) ALDH1A1MAPTHPGD
SCHEMBL5533616 0.65 GAA (0.43) KMT2AMEN1ALDH1A1MAPTSMN1; SMN2
SCHEMBL5531204 0.65 NPC1 (0.47) KMT2AMEN1ALDH1A1NPC1MAPT
SCHEMBL15300326 0.64 NAMPT (0.41) KMT2ALMNAMAPK1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP claimed
EP-1869053-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-26 EP claimed
WO-2006105945-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2006-10-12 WO claimed
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP disclosed
EP-1869053-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-26 EP disclosed
WO-2006105945-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2006-10-12 WO disclosed