Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 4/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | PGK2 | P07205 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 2/20 | 0.30 |
| ▸ | NOS2 | P35228 | 2/20 | 0.30 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18475171 | 0.82 | IDO1 (0.46) | IDO1 | |
| SCHEMBL4957876 | 0.82 | PGK1 (0.42) | ACHEIDO1PGK1PGK2IDH1 | |
| SCHEMBL8340109 | 0.82 | ALDH1A1 (0.40) | ACHEPGK1PGK2IDH1 | |
| SCHEMBL14570491 | 0.80 | ACHE (0.39) | ACHERAPGEF4IDO1NR3C1PGR | |
| SCHEMBL2662788 | 0.78 | ACHE (0.37) | ACHERAPGEF4IDO1NR3C1PGR | |
| SCHEMBL7499745 | 0.78 | ACHE (0.37) | ACHERAPGEF4IDO1NR3C1PGR | |
| SCHEMBL31614540 | 0.76 | LOXL2 (0.42) | ACHERAPGEF4IDO1NR3C1PGR | |
| SCHEMBL16727024 | 0.76 | ACHE (0.36) | ACHERAPGEF4IDO1NR3C1PGR | |
| SCHEMBL2924850 | 0.76 | ACHE (0.36) | ACHERAPGEF4IDO1NR3C1PGR | |
| SCHEMBL4162524 | 0.76 | LOXL2 (0.42) | ACHERAPGEF4IDO1NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2399585-A1 | Boronic acids and esters as inhibitors of fatty acid amide hydrolase | Infinity Pharmaceuticals, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |
| EP-2073816-B1 | BORONIC ACIDS AND ESTERS AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE | INFINITY PHARMACEUTICALS INC (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2008063300-A2 | BORONIC ACIDS AND ESTERS AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE | INFINITY PHARMACEUTICALS, INC. (US) | 2008-05-29 | — | — | WO | disclosed |