Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7630799 | 0.81 | CES2 (0.50) | CES2KIF11ARTSHRMAPK1 | |
| SCHEMBL17141574 | 0.78 | MEN1 (0.44) | CES2MEN1KMT2AKIF11PDE2A | |
| SCHEMBL31618336 | 0.77 | MAPT (0.43) | CES2MEN1KMT2AKIF11PDE2A | |
| SCHEMBL22507938 | 0.77 | PGR (0.46) | CES2MEN1KMT2AKIF11AR | |
| SCHEMBL14016057 | 0.77 | PDE2A (0.47) | CES2MEN1KMT2APDE2ACYP3A4 | |
| SCHEMBL18358786 | 0.76 | KIF11 (0.43) | CES2MEN1KMT2AKIF11PDE2A | |
| SCHEMBL24852666 | 0.74 | ALDH1A1 (0.50) | CES2MEN1KMT2APDE2ACYP3A4 | |
| SCHEMBL1529230 | 0.73 | PDE2A (0.42) | CES2MEN1KMT2AKIF11PDE2A | |
| SCHEMBL31537454 | 0.73 | PDE2A (0.42) | CES2MEN1KMT2AKIF11PDE2A | |
| SCHEMBL19544823 | 0.72 | KIF11 (0.43) | CES2MEN1KMT2AKIF11PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023109912-A1 | 3, 4-DIHYDROISOQUINOLIN-1 (2H) -ONES DERIVATIVES AS STING ANTAGONISTS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-06-22 | — | — | WO | disclosed |