Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 4/20 | 0.42 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16021159 | 0.78 | MCL1 (0.47) | MCL1KCNJ6KCNJ3ALDH1A1MEN1 | |
| SCHEMBL25519675 | 0.78 | ALDH1A1 (0.46) | ALDH1A1TSHRKMT2AL3MBTL1LMNA | |
| SCHEMBL27256998 | 0.76 | MCL1 (0.46) | MCL1KCNJ6KCNJ3MEN1KMT2A | |
| SCHEMBL3088227 | 0.76 | MCL1 (0.49) | MCL1KCNJ6KCNJ3ALDH1A1MEN1 | |
| SCHEMBL17158590 | 0.75 | IDH1 (0.37) | MCL1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL17158467 | 0.75 | IDH1 (0.37) | MCL1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL17158589 | 0.75 | IDH1 (0.37) | MCL1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL17367685 | 0.73 | LMNA (0.59) | MCL1KCNJ6KCNJ3ALDH1A1IDH1 | |
| SCHEMBL14243216 | 0.71 | ALDH1A1 (0.39) | ALDH1A1TSHRSMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL19285885 | 0.70 | ALOX5AP (0.52) | MCL1ALDH1A1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023109912-A1 | 3, 4-DIHYDROISOQUINOLIN-1 (2H) -ONES DERIVATIVES AS STING ANTAGONISTS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-06-22 | — | — | WO | disclosed |