Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30168936 | 0.85 | KDM4E (0.53) | HTTKDM4EGAAALDH1A1MAPT | |
| SCHEMBL21001112 | 0.85 | KDM4E (0.53) | HTTKDM4EGAAALDH1A1MAPT | |
| SCHEMBL23360736 | 0.81 | ALDH1A1 (0.44) | HTTKDM4EGAAALDH1A1MAPT | |
| SCHEMBL25796770 | 0.79 | ALDH1A1 (0.67) | KDM4EGAAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL23168572 | 0.78 | HSD17B10 (0.42) | HTTKDM4EGAAALDH1A1HPGD | |
| SCHEMBL23360731 | 0.77 | KDM4E (0.46) | HTTKDM4EGAAALDH1A1MAPT | |
| SCHEMBL21001153 | 0.76 | ALDH1A1 (0.40) | HTTKDM4EGAAALDH1A1MAPT | |
| SCHEMBL28457664 | 0.75 | ALDH1A1 (0.39) | HTTKDM4EGAAALDH1A1MAPT | |
| SCHEMBL85636 | 0.74 | HTT (0.49) | HTTKDM4EGAAALDH1A1MAPT | |
| SCHEMBL11189883 | 0.74 | HTT (0.49) | HTTKDM4EGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691970-B2 | Pyrazolopyridinone compounds | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11691970-B2 | Pyrazolopyridinone compounds | FGFR1, FGFR3, FGFR2 | HTT 1848/4885KDM4E 964/4885GAA 1537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.