Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.35 |
| ▸ | KDM1A | O60341 | 4/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.32 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25799158 | 0.82 | KDR (0.35) | KDRHDAC1KDM1AHDAC6MEN1 | |
| SCHEMBL30112035 | 0.81 | AR (0.47) | KDRHDAC1KDM1AHDAC6NPC1 | |
| SCHEMBL19556321 | 0.81 | AR (0.47) | KDRHDAC1KDM1AHDAC6NPC1 | |
| SCHEMBL19556320 | 0.81 | AR (0.47) | KDRHDAC1KDM1AHDAC6NPC1 | |
| SCHEMBL16311225 | 0.69 | KDR (0.52) | KDRNPC1RAB9ABRAFKDM4C | |
| SCHEMBL2840910 | 0.66 | CES2 (0.53) | HDAC1HDAC6MEN1NPC1RAB9A | |
| SCHEMBL242724 | 0.64 | KDR (0.53) | KDRNPC1RAB9ABRAFKDM4C | |
| SCHEMBL29940217 | 0.64 | KDR (0.53) | KDRNPC1RAB9ABRAFKDM4C | |
| SCHEMBL17371294 | 0.63 | ALDH1A1 (0.46) | KDRHDAC1KDM1AHDAC6KDM4C | |
| SCHEMBL25804972 | 0.63 | KDR (0.36) | KDRHDAC1KDM1AHDAC6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |