SCHEMBL25801382

SCHEMBL25801382

COc1ccccc1/C=C/c1nc(C)nc(C(Cl)(Cl)Cl)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 5/20 0.45
TRPA1 O75762 1/20 0.45
CYP1A1 P04798 3/20 0.42
CYP1A2 P05177 3/20 0.42
CYP1B1 Q16678 3/20 0.42
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 1/20 0.42
PTGS1 P23219 3/20 0.42
PTGS2 P35354 3/20 0.42
ALOX5 P09917 1/20 0.42
DHFR P00374 1/20 0.41
CYP19A1 P11511 1/20 0.41
TFEB P19484 1/20 0.40
MEN1 O00255 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
KMT2A Q03164 1/20 0.40
ABL1 P00519 2/20 0.39
LCK P06239 2/20 0.39
LYN P07948 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL147047 0.92 NFE2L2 (0.50) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL147046 0.92 NFE2L2 (0.50) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL29402166 0.92 NFE2L2 (0.50) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL153283 0.86 DHFR (0.50) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL26290680 0.83 HRH4 (0.43) CYP1A2KDM4EALDH1A1PTGS2MEN1
SCHEMBL11554723 0.81 NFE2L2 (0.45) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL28754044 0.81 NFE2L2 (0.45) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL15471666 0.79 CYP1A1 (0.49) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL9625468 0.78 KDM4E (0.52) KDM4EALDH1A1MEN1NPC1RAB9A
SCHEMBL12595133 0.77 MAPT (0.48) NFE2L2CYP1A1CYP1A2CYP1B1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11697744-B2 High impact strength 3D printing materials derived from polycycloolefin monomers and crosslinkers PROMERUS, LLC (US) 2023-07-11 US disclosed