SCHEMBL25801971

SCHEMBL25801971

C=C(Cc1nc(Cc2ccc(CCC)cc2)no1)C(=O)OC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.35
▸ ALDH1A1 P00352 1/20 0.34
▸ TSHR P16473 1/20 0.34
▸ HDAC6 Q9UBN7 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25801788 0.94 ALDH1A1 (0.36) MAPTALDH1A1TSHR
SCHEMBL25801811 0.93 ALDH1A1 (0.37) ALDH1A1MEN1KMT2A
SCHEMBL25801848 0.92 L3MBTL1 (0.37) MAPTALDH1A1KMT2AL3MBTL1KDM4E
SCHEMBL23578414 0.88 TP53 (0.38) MAPTALDH1A1TSHRHDAC6MEN1
SCHEMBL23578571 0.88 MAPT (0.35) MAPTALDH1A1TSHRHDAC6MEN1
SCHEMBL23578197 0.88 MAPT (0.47) MAPTALDH1A1TSHRMEN1KMT2A
SCHEMBL25801910 0.88 MAPT (0.41) MAPTALDH1A1HDAC6KDM4E
SCHEMBL23578154 0.86 MEN1 (0.40) MEN1KMT2A
SCHEMBL23578222 0.86 L3MBTL1 (0.37) ALDH1A1KMT2AL3MBTL1
SCHEMBL23588107 0.85 MAPT (0.45) MAPTALDH1A1TSHRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2023-07-13 — — US disclosed
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2023-07-13 — — US disclosed
EP-4081511-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMMATORY PROPERTIES Sitryx Therapeutics Limited (GB) 2022-11-02 — — EP disclosed
CN-115066418-A Carboxy derivatives with anti-inflammatory properties 西特瑞治疗有限公司 2022-09-16 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES CPA2, RO60, C5AR1 MAPT 4683/4885ALDH1A1 134/4885TSHR 3550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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