Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5750248 | 0.87 | TP53 (0.38) | AKT1ALDH1A1TRPA1IDO1CYP1A2 | |
| SCHEMBL18237170 | 0.81 | MEN1 (0.42) | AKT1ALDH1A1CYP2A6TRPA1IDO1 | |
| SCHEMBL10812999 | 0.78 | CYP2A6 (0.48) | ALDH1A1CYP2A6RELANFE2L2TUBB4A | |
| SCHEMBL4769781 | 0.76 | MEN1 (0.46) | ALDH1A1CYP2A6TRPA1MEN1KMT2A | |
| SCHEMBL6496689 | 0.76 | HSD17B10 (0.46) | ALDH1A1CYP2A6TRPA1NFE2L2CYP1A2 | |
| SCHEMBL28597595 | 0.76 | ALDH1A1 (0.44) | ALDH1A1CYP2A6TRPA1IDO1MEN1 | |
| SCHEMBL58240 | 0.76 | IDO1 (0.63) | AKT1TRPA1IDO1MEN1KMT2A | |
| SCHEMBL8988570 | 0.76 | ALDH5A1 (0.46) | ALDH1A1TRPA1MEN1KMT2ARELA | |
| SCHEMBL1230594 | 0.76 | RELA (0.44) | ALDH1A1CYP2A6TRPA1IDO1MEN1 | |
| SCHEMBL792985 | 0.76 | IDO1 (0.63) | AKT1TRPA1IDO1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3007689-A1 | NON-SELECTIVE KINASE INHIBITORS | Zisman, Lawrence, S. (US) | 2016-04-20 | — | — | EP | claimed |
| EP-2988738-A2 | THERAPEUTIC INDICATIONS OF KINASE INHIBITORS | Zisman, Lawrence, S. (US) | 2016-03-02 | — | — | EP | claimed |
| WO-2014110198-A2 | THERAPEUTIC INDICATIONS OF KINASE INHIBITORS | ZISMAN LAWRENCE S (US) | 2014-07-17 | — | — | WO | claimed |
| WO-2014110200-A1 | NON-SELECTIVE KINASE INHIBITORS | ZISMAN LAWRENCE S (US) | 2014-07-17 | — | — | WO | claimed |
| EP-2044063-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | claimed |
| WO-2008001070-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | claimed |
| US-5426106-A | Treatment of neurodegenerative diseases, schizophrenia, convulsions; selective non-competitive antagonists | MERCK SHARP & DOHME LIMITED (GB) | 1995-06-20 | — | — | US | claimed |
| US-5420155-A | Treatment of nervous system disorders with derivatives of 4-hydroxy-2-(1H)-pyrrolones such as strokes, antiischemic agents or cardiovascular disorders | MERCK SHARP & DOHME LTD. (GB) | 1995-05-30 | — | — | US | claimed |
| JP-59044345-A | — | — | None | — | — | JP | disclosed |
| US-11999717-B2 | Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof | GILEAD SCIENCES, INC. (US) | 2024-06-04 | — | — | US | disclosed |
| CN-111743901-B | Spray-dried formulations | 普尔莫凯恩股份有限公司 | 2023-09-12 | — | — | CN | disclosed |
| EP-3054937-B1 | SPRAY DRY FORMULATIONS | PULMOKINE INC (US) | 2023-07-26 | — | — | EP | disclosed |
| US-20230212149-A1 | TRIAZOLE CARBAMATE PYRIDYL SULFONAMIDES AS LPA RECEPTOR ANTAGONISTS AND USES THEREOF | GILEAD SCIENCES, INC. | 2023-07-06 | — | — | US | disclosed |
| US-20230167104-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-06-01 | — | — | US | disclosed |
| WO-1993011115-A2 | QUINOLONE DERIVATIVES AND THEIR USE AS NMDA AND AMPA RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |
| EP-0481676-A1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-04-22 | — | — | EP | disclosed |
| EP-0295839-A2 | Pyrimidine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-12-21 | — | — | EP | disclosed |
| JP-S5944345-A | PREPARATION OPTICAL ACTIVE BETA-AMINO ACID AND ITS INTERMEDIATE | TOYO JOZO CO LTD | 1984-03-12 | — | — | JP | disclosed |
| EP-0039312-A1 | Colour photopgraphic material for the silver-dye bleaching process, process for the production of this material and its use in the production of photographic images | CIBA-GEIGY AG (CH) | 1981-11-04 | — | — | EP | disclosed |
| US-4001284-A | PRIMARY AMINES, 2,4-DIPHENOXY-5-SULFAMOYLBENZOIC ACID | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11999717-B2 | Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof | LPAR3, LPAR1, LPAR2 | AKT1 1512/4885ALDH1A1 2326/4885CYP2A6 2471/4885 |
| US-20230212149-A1 | TRIAZOLE CARBAMATE PYRIDYL SULFONAMIDES AS LPA RECEPTOR ANTAGONISTS AND USES THEREOF | LPAR3, LPAR1, LPAR2 | AKT1 1512/4885ALDH1A1 2326/4885CYP2A6 2471/4885 |
| US-20230167104-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | CLK1, CLK2, CLK3 | AKT1 624/4885ALDH1A1 2647/4885CYP2A6 4313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.