Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2582523 | 0.97 | ALDH1A1 (0.57) | ALDH1A1HTTDPP4DPP8MEN1 | |
| SCHEMBL2582158 | 0.93 | ALDH1A1 (0.56) | ALDH1A1HTTDPP4DPP8MEN1 | |
| SCHEMBL28192273 | 0.78 | ALDH1A1 (0.96) | ALDH1A1HTTDPP4DPP8SIGMAR1 | |
| SCHEMBL2585925 | 0.77 | SIGMAR1 (0.49) | ALDH1A1HTTSIGMAR1RAB9AKCNQ2 | |
| SCHEMBL24709815 | 0.77 | ALDH1A1 (0.50) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL13293320 | 0.77 | ALDH1A1 (1.00) | ALDH1A1HTTDPP4DPP8SIGMAR1 | |
| Bromide SCHEMBL28904918 | 0.76 | ALDH1A1 (0.49) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| Bromide SCHEMBL30110681 | 0.76 | ALDH1A1 (0.49) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL7401709 | 0.75 | ALDH1A1 (0.96) | ALDH1A1HTTDPP4DPP8SIGMAR1 | |
| SCHEMBL4101414 | 0.74 | ALDH1A1 (0.89) | ALDH1A1HTTDPP4DPP8SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048877-B2 | Guanidine derivatives and their medical use | NEUROSEARCH A/S (DK) | 2011-11-01 | — | — | US | claimed |
| US-20090099208-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | ACESION PHARMA APS (DK) | 2009-04-16 | — | — | US | claimed |
| US-8048877-B2 | Guanidine derivatives and their medical use | NEUROSEARCH A/S (DK) | 2011-11-01 | — | — | US | disclosed |
| US-20090099208-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | ACESION PHARMA APS (DK) | 2009-04-16 | — | — | US | disclosed |
| EP-2001853-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007110363-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2007-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099208-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | KCNN2, KCNN1, KCNN3 | ALDH1A1 4060/4885HTT 1288/4885DPP4 1995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.