Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CLPP | Q16740 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2582158 | 0.83 | ALDH1A1 (0.56) | SIGMAR1ALDH1A1HTTCLPPROCK2 | |
| SCHEMBL2581178 | 0.77 | ALDH1A1 (0.62) | SIGMAR1ALDH1A1HTTRAB9AKCNQ2 | |
| SCHEMBL2582523 | 0.77 | ALDH1A1 (0.57) | SIGMAR1ALDH1A1HTTRAB9ADRD4 | |
| SCHEMBL16226483 | 0.69 | ALDH1A1 (0.69) | SIGMAR1ALDH1A1HTTDRD4POLB | |
| SCHEMBL24709815 | 0.69 | ALDH1A1 (0.50) | ALDH1A1HTTPOLB | |
| SCHEMBL11174174 | 0.69 | SIGMAR1 (1.00) | SIGMAR1RAB9APOLB | |
| Bromide SCHEMBL28904918 | 0.68 | ALDH1A1 (0.49) | ALDH1A1HTTPOLB | |
| Bromide SCHEMBL30110681 | 0.68 | ALDH1A1 (0.49) | ALDH1A1HTTPOLB | |
| SCHEMBL2583069 | 0.68 | NOD1 (0.43) | SIGMAR1ALDH1A1HTTCLPPPOLB | |
| SCHEMBL2583741 | 0.68 | SIGMAR1 (0.54) | SIGMAR1ALDH1A1HTTRAB9ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048877-B2 | Guanidine derivatives and their medical use | NEUROSEARCH A/S (DK) | 2011-11-01 | — | — | US | claimed |
| US-20090099208-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | ACESION PHARMA APS (DK) | 2009-04-16 | — | — | US | claimed |
| EP-2001853-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2008-12-17 | — | — | EP | claimed |
| WO-2007110363-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2007-10-04 | — | — | WO | claimed |
| US-8048877-B2 | Guanidine derivatives and their medical use | NEUROSEARCH A/S (DK) | 2011-11-01 | — | — | US | disclosed |
| US-20090099208-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | ACESION PHARMA APS (DK) | 2009-04-16 | — | — | US | disclosed |
| EP-2001853-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007110363-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2007-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099208-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | KCNN2, KCNN1, KCNN3 | SIGMAR1 1377/4885ALDH1A1 4060/4885HTT 1288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.