Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.40 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25487489 | 0.84 | FAAH (0.41) | DRD2DRD4DRD3FAAHMGLL | |
| SCHEMBL20566667 | 0.82 | MGLL (0.57) | SLC6A2FAAHMGLLMEN1CYP3A4 | |
| SCHEMBL20778554 | 0.73 | MGLL (0.57) | MGLL | |
| SCHEMBL19582597 | 0.69 | MAPT (0.42) | SLC6A2SIGMAR1MEN1CYP2D6TSHR | |
| SCHEMBL10238584 | 0.69 | FAAH (0.56) | DRD2DRD4DRD3SLC6A2CYP2A6 | |
| SCHEMBL15084320 | 0.69 | DRD2 (0.54) | DRD2DRD4DRD3CYP2A6ASIC3 | |
| SCHEMBL1556809 | 0.66 | CYP2D6 (0.50) | SIGMAR1MEN1CYP3A4CYP2D6TSHR | |
| SCHEMBL807399 | 0.66 | DRD2 (0.47) | DRD2DRD4DRD3SLC6A2CYP2A6 | |
| SCHEMBL19603152 | 0.65 | SIGMAR1 (0.49) | SLC6A2SIGMAR1MEN1KMT2A | |
| SCHEMBL13499604 | 0.64 | FAAH (0.57) | DRD2DRD4DRD3SLC6A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675847-B1 | SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | H LUNDBECK AS (DK) | 2023-07-12 | — | — | EP | disclosed |