Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 3/20 | 0.37 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | STK25 | O00506 | 1/20 | 0.34 |
| ▸ | YAP1 | P46937 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591509 | 0.79 | ALDH1A1 (0.44) | LMNAALDH1A1MEN1KMT2AGLA | |
| SCHEMBL2592617 | 0.74 | MAP2K4 (0.41) | MAP2K4LMNAMAPT | |
| SCHEMBL2593108 | 0.74 | NQO2 (0.40) | LMNAALDH1A1GLAMAPT | |
| SCHEMBL2592029 | 0.70 | MCL1 (0.41) | MAP2K4MAP2K7ALDH1A1TP53MEN1 | |
| SCHEMBL12180879 | 0.68 | KMT2A (0.39) | LMNAALDH1A1NPC1MEN1KMT2A | |
| SCHEMBL21292761 | 0.65 | KMT2A (0.62) | LMNAALDH1A1TP53KMT2APOLB | |
| SCHEMBL28257095 | 0.62 | ALDH1A1 (0.74) | LMNAALDH1A1KMT2APARGPOLB | |
| SCHEMBL2589397 | 0.61 | OPRK1 (0.38) | LMNAPOLB | |
| SCHEMBL21545492 | 0.60 | NPC1 (0.55) | LMNAALDH1A1NPC1TP53KMT2A | |
| SCHEMBL2584137 | 0.59 | OPRK1 (0.42) | MAP2K4MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566328-A1 | INDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140325-A1 | INDAZOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | disclosed |