Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26743342 | 0.78 | HRH2 (0.40) | HSD11B1ALDH1A1KMT2A | |
| SCHEMBL23729436 | 0.77 | HSD11B1 (0.44) | POLBHSD11B1KDM4ETDP1ALDH1A1 | |
| SCHEMBL22374865 | 0.76 | PIK3CD (0.49) | POLBKDM4EALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL13492941 | 0.75 | ALDH1A1 (0.53) | POLBHSD11B1KDM4ETDP1ALDH1A1 | |
| SCHEMBL23729167 | 0.75 | HSD11B1 (0.42) | POLBHSD11B1KDM4ETDP1ACHE | |
| SCHEMBL26746316 | 0.74 | GAA (0.42) | HSD11B1ALDH1A1MAPTKMT2AL3MBTL1 | |
| SCHEMBL22374861 | 0.74 | BDKRB1 (0.35) | POLBKDM4ETDP1ALDH1A1BDKRB1 | |
| SCHEMBL22520691 | 0.74 | KDM4E (0.40) | KDM4EALDH1A1 | |
| SCHEMBL14595383 | 0.72 | NPC1 (0.50) | POLBHSD11B1KDM4ETDP1ACHE | |
| SCHEMBL26143580 | 0.72 | ALDH1A1 (0.61) | KDM4EALDH1A1MAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A9 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |