Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25820132 | 0.80 | ELANE (0.40) | ALOX5APGABRA1GABRB2LOXL2 | |
| SCHEMBL25820073 | 0.78 | PARP1 (0.38) | ALOX5APGABRA1GABRB2LOXL2 | |
| SCHEMBL25822466 | 0.77 | MEN1 (0.38) | ALOX5APGABRA1GABRB2ALDH1A1HPGD | |
| SCHEMBL6464808 | 0.72 | LRRK2 (0.50) | PREPALDH1A1LRRK2TDP1MAP2K1 | |
| SCHEMBL22554335 | 0.72 | MAP2K1 (0.37) | PREPALDH1A1HPGDKDM4EGAA | |
| SCHEMBL26317702 | 0.72 | RAF1 (0.45) | ALDH1A1HPGDKDM4EGAANPC1 | |
| SCHEMBL2494065 | 0.72 | LOXL2 (0.58) | ALDH1A1KDM4EAAK1SMN1; SMN2CYP1A2 | |
| SCHEMBL2659054 | 0.71 | GABRA1 (0.47) | ALOX5APGABRA1GABRB2ALDH1A1SMN1; SMN2 | |
| SCHEMBL9686635 | 0.69 | GABRA1 (0.46) | ALOX5APGABRA1GABRB2ALDH1A1HPGD | |
| SCHEMBL14983825 | 0.69 | GABRA1 (0.46) | ALOX5APGABRA1GABRB2L3MBTL1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
| US-20230183226-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183226-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | ALOX5AP 2673/4885PREP 4227/4885GABRA1 3307/4885 |
| US-20230219927-A1 | AKT3 MODULATORS | AKT3, AKT2, PIK3CA | ALOX5AP 3700/4885PREP 4612/4885GABRA1 3364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.