Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25821003 | 0.82 | KDM4E (0.46) | MAPTMAPK1LMNAHTTALDH1A1 | |
| SCHEMBL22097649 | 0.81 | KMO (0.48) | MAPTLMNAHTTHPGDALDH1A1 | |
| SCHEMBL14059423 | 0.80 | KDM4E (0.50) | MAPTMAPK1HTTHPGDALDH1A1 | |
| SCHEMBL30863327 | 0.79 | VCAM1 (0.66) | VCAM1MAPTPOLBLMNAHPGD | |
| SCHEMBL9503741 | 0.77 | ALDH1A1 (0.59) | VCAM1MAPTPOLBMAPK1LMNA | |
| SCHEMBL14058999 | 0.77 | ATR (0.43) | MAPTHTTHPGDALDH1A1KDM4E | |
| SCHEMBL16344984 | 0.76 | VCAM1 (0.50) | VCAM1MAPTPOLBMAPK1LMNA | |
| SCHEMBL17197998 | 0.76 | VCAM1 (0.61) | VCAM1MAPTPOLBLMNAHPGD | |
| SCHEMBL25338009 | 0.75 | MEN1 (0.46) | MAPTPOLBMAPK1LMNAHPGD | |
| SCHEMBL16344978 | 0.75 | VCAM1 (0.49) | VCAM1MAPTPOLBMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203059-A1 | MACROCYCLIC JAK INHIBITOR AND USES THEREOF | BIOPOLAR HONGYE (NANTONG) PHARMACEUTICAL CO. LTD. (CN) | 2023-06-29 | — | — | US | disclosed |
| US-20230203059-A1 | MACROCYCLIC JAK INHIBITOR AND USES THEREOF | BIOPOLAR HONGYE (NANTONG) PHARMACEUTICAL CO. LTD. (CN) | 2023-06-29 | — | — | US | disclosed |
| EP-4159738-A1 | MACROCYCLIC JAK INHIBITOR AND USES THEREOF | Biopolar Hongye (Guangdong) Pharmaceutical Co. Ltd (CN) | 2023-04-05 | — | — | EP | disclosed |
| WO-2021238818-A1 | MACROCYCLIC JAK INHIBITOR AND USES THEREOF | 百极弘烨（广东）医药科技有限公司 | 2021-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203059-A1 | MACROCYCLIC JAK INHIBITOR AND USES THEREOF | JAK3, JAK2, JAK1 | VCAM1 3872/4885MAPT 2815/4885POLB 1968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.