Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | NSD2 | O96028 | 1/20 | 0.60 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.55 |
| ▸ | HTR1B | P28222 | 2/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8901248 | 0.88 | KDM4E (0.62) | KDM4EALDH1A1SMN1; SMN2NSD2MTNR1A | |
| SCHEMBL25820387 | 0.87 | KDM4E (0.60) | KDM4EALDH1A1SMN1; SMN2NSD2MTNR1A | |
| SCHEMBL18611549 | 0.86 | KDM4E (0.59) | KDM4EALDH1A1SMN1; SMN2NSD2MTNR1A | |
| SCHEMBL18611546 | 0.84 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2NSD2MTNR1A | |
| SCHEMBL25820408 | 0.84 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2NSD2MTNR1A | |
| SCHEMBL13349920 | 0.83 | PLA2G4B (0.56) | LMNAL3MBTL1KMT2AMAPK1 | |
| SCHEMBL13881713 | 0.81 | KDM4E (0.60) | KDM4EALDH1A1SMN1; SMN2NSD2MTNR1A | |
| SCHEMBL4569112 | 0.80 | MTNR1A (0.53) | KDM4EALDH1A1SMN1; SMN2NSD2MTNR1A | |
| SCHEMBL13523837 | 0.80 | SMN1; SMN2 (0.65) | ALDH1A1SMN1; SMN2LMNAL3MBTL1POLB | |
| SCHEMBL19291375 | 0.80 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2NSD2MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230218549-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230218549-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ALDH1A2, CLN6, AGER | KDM4E 2227/4885ALDH1A1 133/4885SMN1; SMN2 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.