Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 3/20 | 0.46 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.44 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | F8 | P00451 | 1/20 | 0.40 |
| ▸ | F5 | P12259 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31215857 | 1.00 | CCR5 (0.46) | CCR5USP28USP25SLC6A4MAPT | |
| SCHEMBL29227166 | 0.84 | CCR5 (0.49) | CCR5MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18002339 | 0.83 | MRGPRX4 (0.49) | CCR5USP28USP25SLC6A4KMT2A | |
| SCHEMBL25810385 | 0.82 | USP28 (0.50) | CCR5USP28USP25SLC6A4MAPT | |
| SCHEMBL29227165 | 0.82 | CYP19A1 (0.56) | CCR5MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7819820 | 0.82 | MAPT (0.56) | CCR5MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23673334 | 0.81 | USP28 (0.60) | CCR5USP28USP25SLC6A4MAPT | |
| SCHEMBL30038784 | 0.81 | USP28 (0.60) | CCR5USP28USP25SLC6A4MAPT | |
| SCHEMBL23673335 | 0.80 | KMT2A (0.54) | USP28USP25SLC6A4MAPTNPC1 | |
| SCHEMBL4342277 | 0.79 | MAOA (0.48) | CCR5MAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122298-A1 | PROTEIN STABILIZING COMPOUNDS CONTAINING USP28 AND/OR USP25 TARGETING LIGANDS | Stablix, Inc. (US) | 2023-06-29 | — | — | WO | disclosed |