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Sugi Predict / Compounds / SCHEMBL25824044

SCHEMBL25824044

SCHEMBL25824044

CC[C@H]1O[C@@H](n2cc(C(=O)NCc3ccccc3)c(=O)[nH]c2=O)[C@@H](O[Si](C)(C)C(C)(C)C)C1O

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ TK2 O00142 10/20 0.42
▸ KDM4E B2RXH2 2/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ HPGD P15428 1/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ HINT1 P49773 1/20 0.37
▸ P2RY2 P41231 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25824048 0.88 TK2 (0.41) TK2
SCHEMBL25824045 0.85 P2RY2 (0.48) TK2KDM4EALDH1A1HPGDHSD17B10
SCHEMBL23215201 0.85 TYMP (0.46) TK2ALDH1A1HINT1
SCHEMBL10101281 0.81 TK2 (0.53) TK2KDM4EALDH1A1
SCHEMBL29163657 0.81 TK2 (0.53) TK2KDM4EALDH1A1
SCHEMBL10104844 0.81 TK2 (0.53) TK2KDM4EALDH1A1
SCHEMBL17576576 0.79 TK2 (0.53) TK2ALDH1A1
SCHEMBL17576579 0.79 TK2 (0.53) TK2ALDH1A1
SCHEMBL27093309 0.77 TK2 (0.48) TK2P2RY2
SCHEMBL23216894 0.77 TYMP (0.48) TK2P2RY2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240026358-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2024-01-25 — — US disclosed
US-20230220384-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF WAVE LIFE SCIENCES LTD. (SG) 2023-07-13 — — US disclosed
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