Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.60 |
| ▸ | MMP2 | P08253 | 5/20 | 0.59 |
| ▸ | MMP9 | P14780 | 5/20 | 0.59 |
| ▸ | MMP8 | P22894 | 5/20 | 0.59 |
| ▸ | MMP13 | P45452 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 2/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19739144 | 0.89 | MMP2 (0.60) | NPC1MAPTRAB9ANPBWR1MMP2 | |
| SCHEMBL19739335 | 0.85 | MMP2 (0.53) | NPC1MAPTRAB9ANPBWR1MMP2 | |
| SCHEMBL20982455 | 0.84 | ALDH1A1 (0.67) | NPC1MAPTRAB9AALDH1A1MEN1 | |
| SCHEMBL5566197 | 0.84 | NPC1 (0.78) | NPC1MAPTRAB9ANPBWR1MMP2 | |
| SCHEMBL6526357 | 0.83 | MMP2 (0.70) | NPC1MAPTRAB9ANPBWR1MMP2 | |
| SCHEMBL20982497 | 0.82 | ALDH1A1 (0.66) | NPC1MAPTRAB9AALDH1A1MEN1 | |
| SCHEMBL12470997 | 0.82 | NPBWR1 (0.82) | NPC1MAPTRAB9ANPBWR1MMP2 | |
| SCHEMBL27202458 | 0.82 | HPSE (0.67) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL3183363 | 0.81 | NPBWR1 (0.63) | NPC1MAPTRAB9ANPBWR1MMP2 | |
| SCHEMBL13856173 | 0.81 | NPBWR1 (0.80) | NPC1MAPTRAB9ANPBWR1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295114-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-09-21 | — | — | US | disclosed |
| US-20230183226-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295114-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | NPC1 1106/4885MAPT 3962/4885RAB9A 1430/4885 |
| US-20230183226-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | NPC1 1175/4885MAPT 3999/4885RAB9A 1375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.