Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 7/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8896843 | 0.94 | SMN1; SMN2 (0.44) | ALDH1A1SMN1; SMN2LMNATSHRMEN1 | |
| SCHEMBL7539080 | 0.92 | LMNA (0.46) | ALDH1A1SMN1; SMN2LMNATSHRMEN1 | |
| SCHEMBL3042455 | 0.89 | TSHR (0.44) | ALDH1A1SMN1; SMN2LMNATSHRMEN1 | |
| SCHEMBL10030120 | 0.89 | — | — | |
| SCHEMBL15292867 | 0.86 | ADRB2 (0.38) | ALDH1A1SMN1; SMN2LMNATSHR | |
| Fluoride SCHEMBL28805747 | 0.84 | ADRB2 (0.36) | ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL8161878 | 0.84 | CA1 (0.33) | ALDH1A1TSHRMEN1KMT2ATHRB | |
| Fluoride SCHEMBL27902336 | 0.82 | ALDH1A1 (0.32) | ALDH1A1TSHRMEN1KMT2ATHRB | |
| SCHEMBL708499 | 0.81 | ADRB2 (0.38) | ALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL3482445 | 0.81 | ADRB2 (0.32) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132760-A9 | ANTIBACTERIAL DERIVATIVES OF TOBRAMYCIN | ACHAOGEN, INC. (US) | 2011-11-03 | — | — | WO | disclosed |
| WO-1994015617-A1 | 8A-AZA AND 9A-AZA MACROLIDE ANTIBIOTICS, AND A PROCESS FOR PRODUCING SAME AND METHODS OF USE | MERCK & CO., INC. (US) | 1994-07-21 | — | — | WO | disclosed |