Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.46 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.46 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 2/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | ICMT | O60725 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24010750 | 0.80 | GAK (0.64) | GAKRIPK2COQ8ANLKPDE5A | |
| SCHEMBL25846078 | 0.78 | ROCK2 (0.50) | GAKRIPK2COQ8ANLKSLC22A12 | |
| SCHEMBL25827570 | 0.76 | LOXL2 (0.42) | AAK1 | |
| SCHEMBL23999791 | 0.76 | GAK (0.49) | GAKRIPK2COQ8ANLKPDE5A | |
| SCHEMBL25830778 | 0.75 | KDM5A (0.44) | IDO1 | |
| SCHEMBL25830987 | 0.75 | GAK (0.46) | GAKRIPK2KDRIDO1AAK1 | |
| SCHEMBL25846276 | 0.75 | SLC2A1 (0.43) | IDO1 | |
| SCHEMBL21138128 | 0.73 | GAK (0.46) | GAKRIPK2COQ8ANLKPDE5A | |
| SCHEMBL25821192 | 0.72 | CDK8 (0.45) | GAKRIPK2COQ8ANLKPDE5A | |
| SCHEMBL31432137 | 0.72 | TRPV4 (0.38) | ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | AKT3, AKT2, PIK3CA | GAK 493/4885RIPK2 830/4885COQ8A 296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.