SCHEMBL25831010

SCHEMBL25831010

Nc1ccc(C2CCN(C3CN(C(=O)C(F)(F)F)C3)CC2)cc1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC18A3 Q16572 3/20 0.47
ESRRB O95718 1/20 0.39
ESRRG P62508 1/20 0.39
P2RY14 Q15391 1/20 0.38
KDM1A O60341 1/20 0.38
CCR2 P41597 3/20 0.36
KCNH2 Q12809 1/20 0.36
MGLL Q99685 2/20 0.36
TACR1 P25103 2/20 0.36
JAK3 P52333 2/20 0.36
BTK Q06187 2/20 0.36
GRIN2B Q13224 2/20 0.35
L3MBTL3 Q96JM7 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
EGFR P00533 1/20 0.35
LCK P06239 1/20 0.35
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25585276 0.90 SLC18A3 (0.47) SLC18A3ESRRBESRRGP2RY14KDM1A
SCHEMBL2452371 0.86 KDM1A (0.48) SLC18A3P2RY14KDM1AKCNH2
SCHEMBL25830890 0.80 GFER (0.49) MGLLESR2
SCHEMBL3515888 0.75 SLC18A3 (0.60) SLC18A3ESRRBESRRGGRIN2BESR1
SCHEMBL693504 0.74 L3MBTL3 (0.51) L3MBTL3L3MBTL1
SCHEMBL14112122 0.73 KDM1A (0.51) SLC18A3KDM1ACCR2
SCHEMBL25169528 0.72 SLC18A3 (0.51) SLC18A3ESRRBESRRGCCR2GRIN2B
SCHEMBL14320844 0.72 SLC18A3 (0.66) SLC18A3ESRRBESRRGGRIN2BESR1
SCHEMBL26754753 0.72 CTSB (0.30)
SCHEMBL20705482 0.72 RAB9A (0.50) SLC18A3P2RY14KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023125944-A1 COMPOUND CONTAINING HETEROCYCLIC RING 正大天晴药业集团股份有限公司 2023-07-06 WO disclosed