Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPI1 | P60174 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28626698 | 0.79 | FFAR1 (0.48) | TPI1S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL5974079 | 0.77 | LPAR3 (0.39) | TPI1S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL8496986 | 0.73 | MCL1 (0.36) | ALDH1A1 | |
| SCHEMBL7158770 | 0.73 | LPAR3 (0.41) | S1PR4S1PR1S1PR3S1PR5GRM4 | |
| SCHEMBL13104241 | 0.73 | FFAR1 (0.42) | S1PR4S1PR1S1PR3S1PR5DGAT1 | |
| SCHEMBL14878232 | 0.71 | TPI1 (0.64) | TPI1MMP2MMP3MMP8ALDH1A1 | |
| SCHEMBL11606163 | 0.71 | LPAR3 (0.40) | S1PR4S1PR1S1PR3S1PR5GRM4 | |
| SCHEMBL628929 | 0.71 | DGAT1 (0.42) | S1PR4S1PR1S1PR3S1PR5GRM4 | |
| SCHEMBL13104247 | 0.71 | LPAR3 (0.35) | TPI1S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL23959178 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4209483-A1 | PRODRUG MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2023-07-12 | — | — | EP | disclosed |