Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.40 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25833794 | 0.86 | BACE1 (0.47) | BACE1EGLN1TRIM58HRH3CYP2D6 | |
| SCHEMBL3971869 | 0.78 | BACE1 (0.71) | BACE1HRH3CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL9248826 | 0.73 | MAPT (0.60) | KMT2A | |
| SCHEMBL16573747 | 0.72 | BACE1 (0.41) | BACE1GAAKMT2AHRH3CYP2D6 | |
| SCHEMBL22777973 | 0.70 | BACE1 (0.49) | BACE1HRH3CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL29799170 | 0.70 | LMNA (0.46) | GAA | |
| SCHEMBL2535170 | 0.70 | LMNA (0.46) | GAA | |
| SCHEMBL4331978 | 0.70 | SLC6A2 (0.68) | CYP2D6SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL8696003 | 0.70 | GAA (0.52) | GAAKMT2ADHODH | |
| SCHEMBL9259735 | 0.70 | ACHE (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133217-A1 | 2-(INDAZOL-5-YL)-6-(PIPERIDIN-4-YL)-1,7-NAPHTHYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES | REMIX THERAPEUTICS INC. (US) | 2023-07-13 | — | — | WO | disclosed |