SCHEMBL258355

SCHEMBL258355

ClCc1ccc(-c2cccc(-c3ccc(CCl)cc3)c2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 5/20 0.52
MEN1 O00255 1/20 0.48
ESR1 P03372 1/20 0.48
KMT2A Q03164 1/20 0.48
MAOB P27338 4/20 0.47
CYP3A4 P08684 4/20 0.42
HSD17B1 P14061 2/20 0.42
HSD17B2 P37059 2/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C19 P33261 1/20 0.42
HRH3 Q9Y5N1 1/20 0.42
ABL1 P00519 1/20 0.41
ABCB1 P08183 1/20 0.41
BCR P11274 1/20 0.41
APP P05067 1/20 0.41
CYP17A1 P05093 3/20 0.40
CYP11B1 P15538 3/20 0.40
CYP11B2 P19099 3/20 0.40
CYP19A1 P11511 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1309244 0.91 TAAR1 (0.48) TAAR1MEN1ESR1KMT2AMAOB
SCHEMBL22156858 0.87 HRH3 (0.41) TAAR1ESR1MAOBHRH3CYP17A1
SCHEMBL11066208 0.85 TAAR1 (0.44) TAAR1MEN1KMT2AMAOB
SCHEMBL1071609 0.84 TAAR1 (0.56) TAAR1MEN1KMT2ACYP3A4CYP17A1
SCHEMBL9456876 0.84 HRH3 (0.47) TAAR1MAOBCYP2D6CYP2C19HRH3
SCHEMBL187751 0.84 HRH3 (0.47) TAAR1MAOBCYP2D6CYP2C19HRH3
Water SCHEMBL28351968 0.82 TAAR1 (0.54) TAAR1MEN1KMT2ACYP3A4CYP17A1
Hydrochloric Acid SCHEMBL28118118 0.82 TAAR1 (0.54) TAAR1MEN1KMT2ACYP3A4CYP2D6
Water SCHEMBL11480029 0.81 HRH3 (0.45) TAAR1MAOBCYP2D6CYP2C19HRH3
SCHEMBL20777101 0.80 MAOB (0.66) MAOBCYP3A4HSD17B2CYP2C9CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2514788-B1 Phosphorus-sulfur flame retardant additives and polymer systems containing same DOW GLOBAL TECHNOLOGIES LLC (US) 2017-02-01 EP disclosed
EP-2514788-A1 Phosphorus-sulfur flame retardant additives and polymer systems containing same Dow Global Technologies LLC (US) 2012-10-24 EP disclosed
US-8058332-B2 Phosphorus-sulfur FR additives and polymer systems containing same DOW GLOBAL TECHNOLOGIES LLC (US) 2011-11-15 US disclosed
US-20110034573-A1 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME THE DOW CHEMICAL COMPANY 2011-02-10 US disclosed
EP-2125946-A2 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME Dow Global Technologies Inc. (US) 2009-12-02 EP disclosed
WO-2008088487-A2 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME DOW GLOBAL TECHNOLOGIES, INC. (US) 2008-07-24 WO disclosed
US-20080153950-A1 Phosphorus-sulfur FR additives and polymer systems containing same DCOMCO, INC. 2008-06-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080153950-A1 Phosphorus-sulfur FR additives and polymer systems containing same TST, FRG1, PFAS TAAR1 2961/4885MEN1 4452/4885ESR1 666/4885
US-20110034573-A1 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME TST, FRG1, PFAS TAAR1 2961/4885MEN1 4452/4885ESR1 666/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.