Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | RHOC | P08134 | 1/20 | 0.48 |
| ▸ | RHOA | P61586 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CCR5 | P51681 | 5/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25834424 | 0.82 | HCAR3 (0.57) | — | |
| SCHEMBL31285611 | 0.81 | NAMPT (0.51) | NAMPTKMT2AEPHX2LMNATSHR | |
| SCHEMBL912370 | 0.80 | KDM4E (0.49) | NAMPTKMT2AEPHX1 | |
| SCHEMBL28883063 | 0.77 | HPGD (0.50) | NAMPT | |
| SCHEMBL25834884 | 0.77 | HCAR3 (0.58) | EPHX2 | |
| SCHEMBL6844682 | 0.76 | HCAR3 (0.47) | NAMPTEPHX2LMNA | |
| SCHEMBL15058756 | 0.75 | ALDH1A1 (0.60) | KMT2AMAPTLMNAHSD11B1 | |
| SCHEMBL1948437 | 0.75 | MGLL (0.49) | NAMPTKMT2ALMNATSHR | |
| SCHEMBL2207893 | 0.75 | HPGD (0.66) | LMNAHSD11B1 | |
| SCHEMBL12082834 | 0.75 | GABRD (0.63) | KMT2AMAPTLMNAHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023137356-A1 | 15-PGDH INHIBITORS | VENTYX BIOSCIENCES, INC. (US) | 2023-07-20 | — | — | WO | disclosed |