Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25835992 | 0.89 | ALDH1A1 (0.42) | PPARGPPARAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL15539932 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL24251635 | 0.79 | ALDH1A1 (0.59) | PPARGPPARAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL1127697 | 0.78 | PPARG (0.58) | PPARGPPARAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL7362472 | 0.77 | CHRM1 (0.45) | PPARGPPARAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL19695792 | 0.77 | ALDH1A1 (0.42) | PPARGPPARAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL8790782 | 0.77 | CHRM1 (0.47) | PPARGPPARAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL1393589 | 0.76 | MC4R (0.53) | ALDH1A1CYP1A2CYP2C19SIGMAR1POLB | |
| SCHEMBL19695791 | 0.76 | SIGMAR1 (0.52) | ALDH1A1SIGMAR1MEN1POLBKMT2A | |
| SCHEMBL24943926 | 0.76 | KDM4E (0.50) | ALDH1A1MAPK1L3MBTL1SMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219986-A1 | NOVEL AMINOPYRIMIDINE EGFR INHIBITOR | QILU PHARMACEUTICAL CO., LTD. (CN) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219986-A1 | NOVEL AMINOPYRIMIDINE EGFR INHIBITOR | EGFR, ERBB2, ERBB4 | PPARG 963/4885PPARA 1699/4885ALDH1A1 2690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.