Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1981177 | 0.86 | CYP2D6 (0.69) | SIGMAR1KMT2APOLBCYP2D6CYP2C9 | |
| SCHEMBL16786536 | 0.81 | SIGMAR1 (0.58) | SIGMAR1KMT2APOLBCYP2D6CYP2C9 | |
| SCHEMBL11668979 | 0.79 | BRD4 (0.52) | KMT2APOLBCYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2584872 | 0.78 | ALDH1A1 (0.55) | POLBLMNASMN1; SMN2HTTRAB9A | |
| SCHEMBL16416392 | 0.77 | KMT2A (0.76) | SIGMAR1KMT2APOLBCYP2D6CYP2C9 | |
| SCHEMBL11052192 | 0.77 | KMT2A (0.59) | SIGMAR1KMT2APOLBCYP2D6CYP2C9 | |
| SCHEMBL6744475 | 0.77 | SIGMAR1 (0.54) | SIGMAR1KMT2APOLBCYP2D6CYP2C9 | |
| SCHEMBL29450073 | 0.77 | KMT2A (0.76) | SIGMAR1KMT2APOLBCYP2D6CYP2C9 | |
| SCHEMBL246385 | 0.75 | SIGMAR1 (0.48) | SIGMAR1KMT2APOLBCYP2D6CYP2C9 | |
| SCHEMBL11744917 | 0.75 | L3MBTL1 (0.54) | SIGMAR1KMT2APOLBCYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048877-B2 | Guanidine derivatives and their medical use | NEUROSEARCH A/S (DK) | 2011-11-01 | — | — | US | disclosed |
| US-20090099208-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | ACESION PHARMA APS (DK) | 2009-04-16 | — | — | US | disclosed |
| EP-2001853-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007110363-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2007-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099208-A1 | NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE | KCNN2, KCNN1, KCNN3 | SIGMAR1 1377/4885KMT2A 1686/4885POLB 4457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.