Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3128121 | 0.84 | CA12 (0.52) | L3MBTL1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL15576273 | 0.80 | LMNA (0.49) | KMT2AL3MBTL1MEN1HDAC3HDAC4 | |
| SCHEMBL18893559 | 0.80 | MEN1 (0.54) | KMT2AHTR7MEN1PARP1PARP15 | |
| SCHEMBL3641509 | 0.79 | HDAC2 (0.76) | KMT2AMEN1HDAC3HDAC4HDAC1 | |
| SCHEMBL3957423 | 0.79 | OPRM1 (0.63) | KMT2APKMMEN1OPRM1OPRD1 | |
| SCHEMBL14292097 | 0.79 | AURKA (0.59) | NPC1RAB9A | |
| SCHEMBL10189495 | 0.79 | PARP1 (0.56) | L3MBTL1OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL11277128 | 0.78 | AKR1C3 (0.57) | KMT2AHTR7MEN1PARP1PARP15 | |
| SCHEMBL20997878 | 0.77 | L3MBTL1 (0.49) | L3MBTL1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9448609 | 0.77 | NPC1 (0.56) | KMT2APKML3MBTL1HTR7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |