Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6409773 | 0.82 | MAPT (0.42) | MAPTUSP2POLBSMN1; SMN2LMNA | |
| SCHEMBL2400832 | 0.81 | GPR119 (0.37) | MAPTUSP2POLBGPR119NAMPT | |
| SCHEMBL2401980 | 0.78 | TSHR (0.46) | MAPTUSP2POLBMAPK1HTT | |
| SCHEMBL2399685 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2HTTGPR119GAAJAK2 | |
| SCHEMBL2401291 | 0.74 | L3MBTL1 (0.47) | MAPTPOLBLMNAGPR119MEN1 | |
| SCHEMBL2402983 | 0.73 | L3MBTL1 (0.46) | POLBSMN1; SMN2LMNAMAPK1HTT | |
| SCHEMBL2400307 | 0.72 | CYP2D6 (0.44) | MAPTMAPK1CYP2C19GAACYP1A2 | |
| SCHEMBL2402651 | 0.71 | HPGD (0.43) | MAPTUSP2SMN1; SMN2LMNAHTT | |
| SCHEMBL2399298 | 0.71 | RAB9A (0.56) | MAPTUSP2POLBSMN1; SMN2MAPK1 | |
| SCHEMBL2404697 | 0.71 | GNAI3 (0.39) | GPR119CYP2C19CYP3A4RECQLMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048890-B2 | Analgesics; neuropathic pain; headaches; muscle relaxants; incontence; tinnitus; diarrhea; antiarrhythmia agents; antiischemic agents; antiinflammatory agents; antiulcer agents; antidepressants; antiepileptic agents | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | claimed |