Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2915228 | 0.78 | HSD11B1 (0.53) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL27183089 | 0.75 | HSD11B1 (0.54) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL24688313 | 0.74 | HSD11B1 (0.50) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL24740725 | 0.74 | HSD11B1 (0.49) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL25832730 | 0.74 | HSD11B1 (0.50) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5473684 | 0.69 | ALDH1A1 (0.46) | HSD11B1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5476374 | 0.69 | ALDH1A1 (0.46) | HSD11B1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6602310 | 0.68 | KCNH2 (0.55) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5476467 | 0.68 | HSD11B1 (0.44) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL27793875 | 0.68 | HSD11B1 (0.62) | HSD11B1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | AKT3, AKT2, PIK3CA | HSD11B1 1141/4885CHRNB2 4253/4885CHRNB4 3919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.