Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23015829 | 0.86 | HSD11B1 (0.42) | HSD11B1SCN9AKEAP1ALDH1A1KDM4E | |
| SCHEMBL24688313 | 0.86 | HSD11B1 (0.50) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL24740725 | 0.85 | HSD11B1 (0.49) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL12049355 | 0.84 | SCN9A (0.43) | HSD11B1SCN9AKEAP1ALDH1A1KDM4E | |
| SCHEMBL27183089 | 0.83 | HSD11B1 (0.54) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL24921048 | 0.81 | SCN9A (0.44) | HSD11B1SCN9AKEAP1ALDH1A1KDM4E | |
| SCHEMBL25832730 | 0.81 | HSD11B1 (0.50) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL25847427 | 0.78 | HSD11B1 (0.47) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5476374 | 0.76 | ALDH1A1 (0.46) | HSD11B1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5473684 | 0.76 | ALDH1A1 (0.46) | HSD11B1ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263722-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING AZETIDINE DERIVATIVES, NOVEL AZETIDINE DERIVATIVES AND PREPARATION THEREOF | AVENTIS PHARMA SA (FR) | 2010-08-25 | — | — | EP | disclosed |
| CN-1418192-A | Pharmaceutical compositions containing azetidine derivatives novel azetidine derivatives and preparation thereof | AVENTIS PHARMA SA (FR) | 2003-05-14 | — | — | CN | disclosed |
| EP-1263722-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING AZETIDINE DERIVATIVES, NOVEL AZETIDINE DERIVATIVES AND PREPARATION THEREOF | Aventis Pharma S.A. (FR) | 2002-12-11 | — | — | EP | disclosed |
| US-6355631-B1 | TREATMENT OF PSYCHOSIS AND SCHIZOPHRENIA | AVENTIS PHARMA S.A. (FR) | 2002-03-12 | — | — | US | disclosed |
| WO-2001064634-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING AZETIDINE DERIVATIVES, NOVEL AZETIDINE DERIVATIVES AND PREPARATION THEREOF | AVENTIS PHARMA S.A. (FR) | 2001-09-07 | — | — | WO | disclosed |