Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4270004 | 0.82 | POLB (0.53) | POLBGAAALDH1A1TSHRL3MBTL1 | |
| SCHEMBL2584836 | 0.72 | HSP90AA1 (0.49) | POLBGAAHSP90AA1ALDH1A1TSHR | |
| SCHEMBL2576088 | 0.69 | HSP90AA1 (0.54) | POLBGAAHSP90AA1ALDH1A1LMNA | |
| SCHEMBL2586009 | 0.69 | HSP90AA1 (0.53) | POLBGAAHSP90AA1ALDH1A1NPSR1 | |
| SCHEMBL2579235 | 0.68 | HSP90AA1 (0.51) | GAAHSP90AA1ALDH1A1TSHRHDAC3 | |
| SCHEMBL2586692 | 0.68 | RAB9A (0.48) | GAAHSP90AA1ALDH1A1TSHRLMNA | |
| SCHEMBL2584636 | 0.67 | NPC1 (0.44) | POLBGAAHSP90AA1ALDH1A1TSHR | |
| SCHEMBL2587431 | 0.66 | HSP90AA1 (0.46) | GAAHSP90AA1ALDH1A1LMNAKMT2A | |
| SCHEMBL2588891 | 0.63 | HSP90AA1 (0.62) | POLBHSP90AA1ALDH1A1TSHRHDAC3 | |
| SCHEMBL2588237 | 0.62 | SMN1; SMN2 (0.47) | POLBGAAHSP90AA1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |