Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.39 |
| ▸ | PDE4A | P27815 | 4/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28164154 | 0.76 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6877898 | 0.76 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL874503 | 0.76 | PDE4D (0.41) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4594035 | 0.73 | PDE4B (0.45) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL29994875 | 0.72 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL18830718 | 0.72 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL172802 | 0.69 | CXCR5 (0.43) | ALOX5APFEN1 | |
| SCHEMBL28230560 | 0.68 | HTR2C (0.58) | — | |
| SCHEMBL4402862 | 0.68 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL30326107 | 0.67 | PDE4D (0.36) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563789-A1 | 7-(1H-PYRAZOL-4-YL)-1,6-NAPHTHYRIDINE COMPOUNDS AS SYK INHIBITORS | Glaxo Group Limited (GB) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134971-A1 | 7-(1H-PYRAZOL-4-YL)-1,6-NAPHTHYRIDINE COMPOUNDS AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-11-03 | — | — | WO | disclosed |
| EP-2215082-A1 | PHTHALAZINE AND PYRIDO Ý3,4-D¨PYRIDAZ INE COMPOUNDS AS H1 RECEPTOR ANTAGONISTS | Glaxo Group Limited (GB) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009047336-A1 | PHTHALAZINE AND PYRIDO [3,4-D] PYRIDAZ INE COMPOUNDS AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-04-16 | — | — | WO | disclosed |