Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD1 | P11586 | 3/20 | 0.60 |
| ▸ | DHFR | P00374 | 2/20 | 0.58 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.52 |
| ▸ | FPGS | Q05932 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MTHFD2 | P13995 | 3/20 | 0.45 |
| ▸ | ATIC | P31939 | 4/20 | 0.44 |
| ▸ | TYMS | P04818 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levomefolic Acid SCHEMBL79586 | 0.94 | MTHFD1 (0.68) | MTHFD1DHFRSOSTFPGSLMNA | |
| Levomefolic Acid SCHEMBL7953180 | 0.94 | MTHFD1 (0.68) | MTHFD1DHFRSOSTFPGSLMNA | |
| Levomefolic Acid SCHEMBL16466806 | 0.94 | MTHFD1 (0.68) | MTHFD1DHFRSOSTFPGSLMNA | |
| Levomefolic Acid SCHEMBL16490221 | 0.94 | MTHFD1 (0.68) | MTHFD1DHFRSOSTFPGSLMNA | |
| Levomefolic Acid SCHEMBL20440869 | 0.94 | MTHFD1 (0.68) | MTHFD1DHFRSOSTFPGSLMNA | |
| Levomefolic Acid SCHEMBL3442396 | 0.94 | MTHFD1 (0.67) | MTHFD1DHFRSOSTFPGSLMNA | |
| SCHEMBL17931045 | 0.92 | MTHFD1 (0.59) | MTHFD1DHFRSOSTFPGSLMNA | |
| SCHEMBL26045337 | 0.91 | MTHFD1 (0.60) | MTHFD1DHFRSOSTFPGSLMNA | |
| SCHEMBL13300970 | 0.90 | DHFR (0.70) | MTHFD1DHFRSOSTFPGSLMNA | |
| SCHEMBL13477849 | 0.90 | DHFR (0.70) | MTHFD1DHFRSOSTFPGSLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023137403-A2 | COMPOUND COMPRISING RALTITREXED OR 5-MTHF LINKED TO A THERAPEUTIC AGENT, COMPOSITION, AND METHOD OF USE | PURDUE RESEARCH FOUNDATION (US) | 2023-07-20 | — | — | WO | disclosed |