Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 1.00 |
| ▸ | FPGS | Q05932 | 2/20 | 0.89 |
| ▸ | GART | P22102 | 5/20 | 0.75 |
| ▸ | DHFR | P00374 | 1/20 | 0.67 |
| ▸ | ATIC | P31939 | 3/20 | 0.65 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.63 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofolate SCHEMBL30051444 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL1069545 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL4535491 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL9879710 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL8030 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL29435894 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL2691812 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL159231 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL29870853 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL10358931 | 0.99 | SOST (0.98) | SOSTFPGSGARTDHFRATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 879 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12622913-B2 | Folate salts for medical use | APROFOL AG (CH) | 2026-05-12 | — | — | US | claimed |
| US-12318395-B2 | Ethinyl estradiol-β-cyclodextrin complex and process for preparing thereof | LABORATORIOS LEON FARMA, S.A. (ES) | 2025-06-03 | — | — | US | claimed |
| US-12138266-B2 | Folate preparations | APROFOL AG (CH) | 2024-11-12 | — | — | US | claimed |
| WO-2023237484-A1 | COMPOSITIONS COMPRISING DISODIUM 5,10-METHYLENE-(6R)-TETRAHYDROFOLATE | MERCK PATENT GMBH (DE) | 2023-12-14 | — | — | WO | claimed |
| US-20230277544-A1 | FOLATE SALTS FOR MEDICAL USE | APROFOL AG (CH) | 2023-09-07 | — | — | US | claimed |
| US-20230158029-A1 | FOLATE COMPOSITIONS | APROFOL AG (CH) | 2023-05-25 | — | — | US | claimed |
| EP-2991619-B1 | STABLE PHARMACEUTICAL COMPOSITION CONTAINING FOLATES | APROFOL AG (CH) | 2023-01-18 | — | — | EP | claimed |
| EP-4114399-A1 | FOLATE PREPARATIONS FOR THE TREATMENT OF OCULAR DISEASES | Aprofol AG (CH) | 2023-01-11 | — | — | EP | claimed |
| CN-115427046-A | Folic acid substance preparation for treating eye diseases | 阿普罗福尔公司 | 2022-12-02 | — | — | CN | claimed |
| CN-115161359-A | Natural (6S) -5-methyl tetrahydrofolate and preparation method thereof | 连云港金康和信药业有限公司 | 2022-10-11 | — | — | CN | claimed |
| US-5324836-A | Process for the preparation of (6S)- and (6R)-tetrahydrofolic acid | EPROVA AKTEINGESELLSCHAFT (CH) | 1994-06-28 | — | — | US | claimed |
| EP-0600460-A1 | Process for the preparation of 6(S)-5,6,7,8-tetrahydrofolic acid | Cerbios-Pharma S.A. (CH) | 1994-06-08 | — | — | EP | claimed |
| US-5300505-A | Stable salts of 5,10-methylenetetrahydrofolic acid | EPROVA AKTIENGESELLSCHAFT (CH) | 1994-04-05 | — | — | US | claimed |
| WO-1993019069-A1 | INTERMEDIATES AND A PROCESS FOR SYNTHESIS OF TETRAHYDROPTERIDINE C6-STEREOISOMERS, INCLUDING (6S)-TETRAHYDROFOLATE AND N5-FORMYL-(6S)-TETRHYDROFOLATE | BAILEY STEVEN W (US) | 1993-09-30 | — | — | WO | claimed |
| EP-0551642-A1 | Process of diastereoselective hydration of folic acid in tetrahydrofolic acid | BASF Aktiengesellschaft (DE) | 1993-07-21 | — | — | EP | claimed |
| EP-0537492-A2 | Stable salts of 5,10-methylenetetrahydrofolic acid | EPROVA Aktiengesellschaft (CH) | 1993-04-21 | — | — | EP | claimed |
| US-5198547-A | Process for N5-formylating tetrahydropteridines | SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION, USA (US) | 1993-03-30 | — | — | US | claimed |
| CN-1063285-A | Process for the preparation of (6S) -and (6R) -tetrahydrofolic acid | EPROVA AG (CH) | 1992-08-05 | — | — | CN | claimed |
| EP-0495204-A1 | Process for the preparation of (6S)- and (6R)-tetrahydrofolic acid | EPROVA Aktiengesellschaft (CH) | 1992-07-22 | — | — | EP | claimed |
| EP-0348641-A2 | Process for the preparation of tetrahydrofolates | EPROVA Aktiengesellschaft (CH) | 1990-01-03 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230277544-A1 | FOLATE SALTS FOR MEDICAL USE | FOLR2, FOLR1, MTHFD1 | SOST 1573/4885FPGS 11/4885GART 526/4885 |
| US-12622913-B2 | Folate salts for medical use | FOLR2, FOLR1, MTHFD1 | SOST 2142/4885FPGS 16/4885GART 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.