Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 1.00 |
| ▸ | FPGS | Q05932 | 2/20 | 0.89 |
| ▸ | GART | P22102 | 5/20 | 0.75 |
| ▸ | DHFR | P00374 | 1/20 | 0.67 |
| ▸ | ATIC | P31939 | 3/20 | 0.65 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.63 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofolate SCHEMBL258530 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL30051444 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL1069545 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL4535491 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL8030 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL29435894 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL2691812 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL159231 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL29870853 | 1.00 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL10358931 | 0.99 | SOST (0.98) | SOSTFPGSGARTDHFRATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119662627-A | Immobilized double-enzyme resin and preparation method and application thereof | 浙江工业大学 | 2025-03-21 | — | — | CN | claimed |
| CN-119365186-A | Composition comprising disodium 5, 10-methylene- (6R) -tetrahydrofolate | 默克专利股份有限公司 | 2025-01-24 | — | — | CN | claimed |
| CN-115427046-A | Folic acid substance preparation for treating eye diseases | 阿普罗福尔公司 | 2022-12-02 | — | — | CN | claimed |
| CN-115161359-A | Natural (6S) -5-methyl tetrahydrofolate and preparation method thereof | 连云港金康和信药业有限公司 | 2022-10-11 | — | — | CN | claimed |
| CN-113603691-B | Preparation process of L-5-methyl tetrahydrofolic acid calcium | 连云港冠昕医药科技有限公司 | 2022-08-26 | — | — | CN | claimed |
| CN-119662627-A | Immobilized double-enzyme resin and preparation method and application thereof | 浙江工业大学 | 2025-03-21 | — | — | CN | disclosed |
| CN-119662627-A | Immobilized double-enzyme resin and preparation method and application thereof | 浙江工业大学 | 2025-03-21 | — | — | CN | disclosed |
| CN-222524558-U | Reaction device for producing natural folic acid | 连云港金康和信药业有限公司 | 2025-02-25 | — | — | CN | disclosed |
| CN-119365186-A | Composition comprising disodium 5, 10-methylene- (6R) -tetrahydrofolate | 默克专利股份有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-119343131-A | Concentrated solution comprising sodium 5, 10-methylene- (6R) -tetrahydrofolate | 默克专利股份有限公司 | 2025-01-21 | — | — | CN | disclosed |
| CN-119330970-A | Method for recycling and preparing folic acid from (6R) -tetrahydrofolic acid p-toluenesulfonate waste liquid | 湖北楚维药业有限公司 | 2025-01-21 | — | — | CN | disclosed |
| CN-119325374-A | Stable lyophilisates comprising 5, 10-methylene- (6R) -tetrahydrofolate | 默克专利股份有限公司 | 2025-01-17 | — | — | CN | disclosed |
| CN-101821401-B | Increasing methionine yield | METABOLIC EXPLORER SA | 2013-10-30 | — | — | CN | disclosed |
| CN-103087971-A | Increasing methionine yield | METABOLIC EXPLORER SA | 2013-05-08 | — | — | CN | disclosed |
| US-20110092453-A1 | TREATMENTS AND PREVENTION OF HYDROCEPHALUS | THE UNIVERSITY OF MANCHESTER (GB) | 2011-04-21 | — | — | US | disclosed |
| CN-101821401-A | Increasing methionine yield | METABOLIC EXPLORER SA | 2010-09-01 | — | — | CN | disclosed |
| US-7172778-B2 | isomers of reduced folate selected from (6S)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid; vitamin B6; birth defect prevention | SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) | 2007-02-06 | — | — | US | disclosed |
| CN-1122456-C | Food and vitamin products containing natural reduced folate isomers | UNIV SOUTH ALABAMA (US) | 2003-10-01 | — | — | CN | disclosed |
| CN-1209729-A | Food and vitamin products containing natural isomer of reduced folates | UNIV SOUTH ALABAMA (US) | 1999-03-03 | — | — | CN | disclosed |
| US-5006655-A | Process for the preparation of tetrahydrofolates | EPROVA AG (CH) | 1991-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092453-A1 | TREATMENTS AND PREVENTION OF HYDROCEPHALUS | DHFR, MTHFD1, MTHFD2 | SOST 2003/4885FPGS 13/4885GART 538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.