Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591965 | 0.86 | L3MBTL1 (0.51) | LMNAL3MBTL1SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL2589947 | 0.86 | MEN1 (0.46) | LMNAL3MBTL1SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL2584750 | 0.71 | HCRTR2 (0.48) | LMNAL3MBTL1SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL2589693 | 0.70 | HCRTR2 (0.47) | LMNAL3MBTL1SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL2586103 | 0.70 | HCRTR2 (0.58) | LMNAL3MBTL1SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL779990 | 0.68 | L3MBTL1 (0.55) | LMNAL3MBTL1SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL5843078 | 0.67 | CYP19A1 (0.46) | LMNAMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL18091142 | 0.66 | HTR6 (0.43) | SMN1; SMN2 | |
| SCHEMBL776710 | 0.66 | TAAR1 (0.47) | LMNAL3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL775777 | 0.65 | TAAR1 (0.50) | L3MBTL1SMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |