Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18038012 | 0.92 | NPC1 (0.54) | BLMAPOBEC3AAPOBEC3GL3MBTL1KMT2A | |
| SCHEMBL18017349 | 0.87 | APOBEC3A (0.44) | BLMAPOBEC3AAPOBEC3GL3MBTL1KMT2A | |
| SCHEMBL25858253 | 0.81 | BLM (0.50) | BLMKMT2AMEN1LMNAMAPT | |
| SCHEMBL24009862 | 0.80 | KMT2A (0.58) | BLMAPOBEC3AAPOBEC3GL3MBTL1KMT2A | |
| SCHEMBL25858218 | 0.79 | SLC2A1 (0.60) | BLMKMT2AMAPTRAB9ANPC1 | |
| SCHEMBL25858213 | 0.78 | KMT2A (0.45) | BLMAPOBEC3AAPOBEC3GL3MBTL1KMT2A | |
| SCHEMBL25734784 | 0.76 | KMT2A (0.47) | BLMAPOBEC3AAPOBEC3GL3MBTL1KMT2A | |
| SCHEMBL25858229 | 0.76 | DNM2 (0.45) | BLMKMT2AMEN1MAPTRAB9A | |
| SCHEMBL18017333 | 0.74 | MEN1 (0.44) | APOBEC3AAPOBEC3GL3MBTL1KMT2AMEN1 | |
| SCHEMBL16319530 | 0.74 | APOBEC3A (0.44) | APOBEC3AAPOBEC3GL3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230321094-A1 | COMBINATION THERAPIES WITH OLIG2 INHIBITORS | Curtana Pharmaceuticals, Inc. | 2023-10-12 | — | — | US | disclosed |
| US-20230271926-A1 | INHIBITION OF OLIG2 ACTIVITY | Curtana Pharmaceuticals, Inc. | 2023-08-31 | — | — | US | disclosed |
| US-11691951-B2 | Inhibition of Olig2 activity | Curtana Pharmaceuticals, Inc. (US) | 2023-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11691951-B2 | Inhibition of Olig2 activity | GLI2, ING2, GMFG | BLM 4472/4885APOBEC3A 4454/4885APOBEC3G 3978/4885 |
| US-20230321094-A1 | COMBINATION THERAPIES WITH OLIG2 INHIBITORS | PAX2, GLI2, RUNX1 | BLM 3317/4885APOBEC3A 4007/4885APOBEC3G 3558/4885 |
| US-20230271926-A1 | INHIBITION OF OLIG2 ACTIVITY | GLI2, ING2, GMFG | BLM 4472/4885APOBEC3A 4454/4885APOBEC3G 3978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.