SCHEMBL25858440

SCHEMBL25858440

CCOCOc1cc(C=O)ccc1-c1nnc(N)c(C2CC2)c1C1CC1

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.35
DHFR P00374 1/20 0.34
FDPS P14324 1/20 0.31
KDM4E B2RXH2 1/20 0.31
TNK2 Q07912 1/20 0.31
TACR2 P21452 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25258312 0.88 ALDH1A1 (0.35) ALDH1A1FDPSKDM4ETACR2
SCHEMBL25858451 0.86 ALDH1A1 (0.34) ALDH1A1FDPSKDM4E
SCHEMBL31314127 0.84 ALDH1A1 (0.35) ALDH1A1DHFRFDPSKDM4ETACR2
SCHEMBL25859857 0.84 ALDH1A1 (0.35) ALDH1A1DHFRFDPSKDM4ETACR2
SCHEMBL29030544 0.83 ALDH1A1 (0.33) ALDH1A1KDM4ETACR2
SCHEMBL31496006 0.83 DHFR (0.35) ALDH1A1DHFRFDPSKDM4ETNK2
SCHEMBL25858043 0.83 DHFR (0.35) ALDH1A1DHFRFDPSKDM4ETNK2
SCHEMBL25858470 0.82 GABRA1 (0.30)
SCHEMBL31314242 0.80 DHFR (0.36) ALDH1A1DHFRFDPSKDM4ETACR2
SCHEMBL25856705 0.80 DHFR (0.36) ALDH1A1DHFRFDPSKDM4ETACR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023131277-A1 NLRP3 INFLAMMASOME INHIBITOR AND USES THEREOF 药捷安康(南京)科技股份有限公司 2023-07-13 WO disclosed